Synbiotic Formula for Optimal Intestinal Health* Supports a healthy gut microflora balance* Provides 10 billion CFU per day from two strains of Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacterium animalis subsp. lactis Includes 600 mg of fructooligosaccharides per serving HLC High Potency Powder is a unique combination of four strains of proprietary, human-sourced probiotics and fructooligosaccharides (FOS) that helps to promote gastrointestinal health in adults. In a randomized, placebo-controlled trial involving 22 adults, daily supplementation with a probiotic containing Lactobacillus acidophilus supported a healthy microflora balance. Lactobacilli and Bifidobacteria, the most commonly used probiotics, help colonize the intestines and mediate the permeability of epithelial cells. After they are fermented by microbes in the colon, prebiotics - including FOS - support the growth of beneficial bacteria in the colon and further maintain the barrier function of intestinal epithelial cells by increasing mucin levels. Their fermentation can result in the production of short chain fatty acids, including butyrate, the preferred energy source of colon cells.* *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 1. Allen, SJ, Wareham, K, Bradley, C, Harris, W, Dhar, A, Brown, H, Foden, A, Cheung, WY, Gravenor, MB, Plummer, S, Phillips, CJ, Mack, D. BMC Infectious Diseases. 2012; 12: 108. 2. Madden, JAJ, Plummer, SF, Tang, J, Garaiova, I, Plummer, NT, Herbison, M, Hunter, JO, Shimada, T, Cheng, L, Shirakawa, T. International Immunopharmacology. 2005; 5: 1091-1097. 3. Mahenthiralingam, E, Marchbank, A, Drevinek, P, Garaiova, I, Plummer, S. Use of colony-based bacterial strain typing for tracking the fate of Lactobacillus strains during human consumption. BMC Microbiology. 2009; 9: 251. 4. Saulnier, N, Zocco, MA, Di Caro, S, Gasbarrini, G, Gasbarrini, A. Probiotics and small bowel mucosa: Molecular aspects of their interactions. Genes & Nutrition. 2006; 1(2): 107-116. 5. Fu, L, Wang, Y. (2013). Chapter 3. Sources and Production of Probiotics. In Otles, S. (Ed.), Probiotics and Prebiotics in Food, Nutrition and Health (pp. 50-64). Boca Raton, FL: CRC Press. 6. Lyra A, Tiihonen K, Lehtinen MJ, Ouwehand AC. (2013). Chapter 8. Pro- and Prebiotics for Elderly. In Otles, S. (Ed.), Probiotics and Prebiotics in Food, Nutrition and Health (pp. 156-178). Boca Raton, FL: CRC Press. Ingredients: Bifidobacterium animalis subsp. lactis (CUL 34), Bifidobacterium bifidum (CUL 20), Dietary Fiber, Fructooligosaccharides (FOS), HLC Consortium, Lactobacillus acidophilus (CUL-21), Lactobacillus acidophilus (CUL-60) Allergens: Gluten Free, Vegetarian
